Beilstein J. Org. Chem.2011,7, 976–979, doi:10.3762/bjoc.7.109
membered cyclic imines. It allows the diversity-oriented synthesis of various tetrahydro[f][1,4]benzoxazepines.
Keywords: benzoxazepines; cyclic imines; longrangestereoinduction; multicomponent reactions; Ugi reaction; Introduction
The Ugi reaction is probably the most renowned and widely used
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Graphical Abstract
Scheme 1:
a) TBAD [(t-BuO2C−N=)2], PPh3, THF, −15 °C → rt, 49% (3a), 62% (3b); b) LiAlH4, Et2O–THF, 0 °C, 90%...